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Case Study

Michael

Longevity and Biological Age Reversal
Chapter Chapter 18
Duration 12 months
Status Resolved
Before Ageing faster than the clock.
→
After An eight-year biological age reversal.
The Story

Longevity and Biological Age Reversal

Michael was 52 with no acute illness. He was proactive. He wanted to optimise before decline set in, not after. When we ran his baseline testing including the TruAge Epigenetic Test, his biological age came back at approximately 56, four years older than his chronological age. He was ageing faster than the clock, and he had no idea.

His blood work showed chronic low-grade inflammation, depleted B12, elevated homocysteine, and low CoQ10. His gut was missing keystone species. His testosterone was declining. None of it was severe enough for a diagnosis, but all of it was compounding into accelerated biological ageing.

The full clinical story Chapter 18 of The Healing Hierarchy Get the Book →
Diagnostics

What we tested. And what we found.

Every protocol in The Healing Hierarchy starts with comprehensive testing. The right tests reveal the actual drivers. Without them, you're treating symptoms.

Tests Used
1
Comprehensive Blood Panel
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2
Organic Acid Tests (OAT)
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3
GI-MAP (Advanced Stool Test)
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4
Hair Tissue Mineral Analysis (HTMA)
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5
TruAge Epigenetic Test (biological age, DunedinPACE, telomere length)
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Key Findings
Biological Age
~56
Chronological 52
CRP
2.8
Optimal : < 1.0
Chronic low-grade inflammation
Homocysteine
10.2
Optimal : < 7
Active B12
285 pmol/L
Optimal : > 500
CoQ10
0.38 μmol/L
Optimal : > 0.8
NAD+ depletion inferred
~40-50%
Decline
Magnesium, Zinc, Selenium
Low
Mercury, lead, aluminium
Low, Chronic
Firmicutes/Bacteroidetes ratio
Ratio suboptimal
Akkermansia, Faecalibacterium
Low
Total Testosterone
380 ng/dL
Fungsional range : 450-900
The Protocol

Sequenced,  not stacked.

The phases are deliberate. Each one prepares the system for the next. Doing them out of order, or all at once, is where most protocols fail.

Phase 1
Foundational Longevity Stack
Daily

Methylated B-complex

Bioenhanced Methyl B →

Vitamin B6 (P-5-P) and magnesium

BioCeuticals Muscleze P5P →

Choline

Biomedica Choline →

CoQ10 (ubiquinol)

Bioclinic Ubiquinol →

PQQ — SH PQQ

NMN

GBH NMN →

Magnesium glycinate

RN Labs Magnesium Glycinate →

Zinc, selenium, molybdenum, silica

AFM Formula A →

Gentle heavy metal detox

Pectasol Modified Citrus Pectin →

NAC

NAC →

Alpha-lipoic acid

Biomedica ALA →

Glycine

GBH Glycine →

Multi-strain probiotic with Akkermansia

Pendulum Akkermansia → Spectrum Pro 8 Forte →

Omega-3

Opti EPA/DHA →

Curcumin

Orthoplex Curcuma Clinical →
Phase 2
Advanced Longevity Compounds

Quercetin and Fisetin (pulse dosing, senolytics)

Orthoplex Quercedran →

Resveratrol

Resveratrol →

EGCG

Panaxea Mega EGCG →

Carnosine (glycation inhibitor)

Ashwagandha and Tongkat Ali for natural testosterone support

SH Testosterone Nutrients →
Phase 3
Lifestyle Optimisation

Diet: Mediterranean-Japanese hybrid, 1.6-2.0 g/kg protein, polyphenol-rich foods

Intermittent fasting: 16:8 daily, quarterly 3-day fasts

Exercise: Zone 2 cardio (4x/week), strength training (3x/week), VO2 max intervals (1x/week)

Sleep: 7-8 hours, magnesium + L-theanine before bed, blue-light blocking

Stress: sauna (3-4x/week), cold exposure (2-3x/week), mindfulness

Phase 4
Monitoring and Iteration

Biomarker retesting every 3-6 months

HTMA recheck at 9-12 months

GI-MAP annually

TruAge Epigenetic Test annually

Adjust protocol based on data

Duration 12 months

Markers  back to baseline.

The biomarkers tell the story. Every value moved from "abnormal" to "optimal" within six months of the protocol going live.

Biological age
56 → ~48 (8-year reversal) Optimal ✓
CRP
2.8 → 0.4 Normal ✓
Homocysteine
10.2 → 6.1 Normal ✓
CoQ10
0.38 → 1.1 μmol/L Normal ✓
Total Testosterone
380 → 620 ng/dL Healthy ✓
Heavy metals:
Significantly decreased Healthy ✓

Energy, strength, and mental clarity improved beyond his mid-40s levels.

Read the full clinical story

Michael's case is  Chapter  18.

The reasoning behind every decision, the sequencing logic, the diagnostic interpretation, and the framework these protocols sit inside, all of it is in the book.

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Important. This protocol was designed for a specific individual based on their unique test results, medical history, genetics, and clinical context. It is presented here for educational purposes only and should not be replicated without professional guidance.

Every person requires an individualised approach. Work with a qualified practitioner who can assess your situation, interpret your test results, and design a protocol tailored to your needs. Supplement links are provided for reference to the practitioner-grade products used in this case. This information does not constitute medical advice, diagnosis, or treatment.