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Case Study

Claire

Pregnancy Loss and Nutrient Restoration
Chapter Chapter 15
Duration 8 months
Status Resolved
Before Unexplained recurrent pregnancy loss.
After Eight months to successful conception.
The Story

Methylation, Pregnancy Loss and Nutrient Restoration

Claire was 38 and had experienced three early pregnancy losses after conceiving her first child easily at 32. Every standard investigation came back normal. She had been diagnosed with unexplained recurrent pregnancy loss and told there was nothing more that could be done.

Her blood work revealed severe B12 depletion and elevated homocysteine. Genetic testing confirmed a double MTHFR mutation that reduced her methylation capacity by 70%. She had been taking a standard prenatal with synthetic folic acid, which her body could not convert. The very supplement designed to support her pregnancy was blocking the pathway she needed most.

The full clinical story Chapter 15 of The Healing Hierarchy Get the Book →
Diagnostics

What we tested. And what we found.

Every protocol in The Healing Hierarchy starts with comprehensive testing. The right tests reveal the actual drivers. Without them, you're treating symptoms.

Tests Used Key Findings
Homocysteine
12.6
Optimal : < 7
Active B12
42 pmol/L
Optimal : > 500
Severely depleted
MTHFR C677T
Homozygous (+/+)
70% reduced enzyme activity
MTHFR A1298C
Heterozygous (+/-)
MTR, MTRR
Variants compounding methylation bottleneck
Pyroglutamic acid
38.5
Normal : ≤ 28
Severe glutathione depletion
Ferritin
28
Optimal : 50-150
Depleted iron stores
Vitamin D
52 nmol/L
Optimal : 80-200
Progesterone (Day 21)
26 nmol/L
Optimal : > 30
Low luteal support
CRP
2.8
Optimal : < 1.0
Calprotectin
88
Normal : < 50
Gut inflammation
Low Lactobacillus
Absent Akkermansia
The Protocol

Sequenced,  not stacked.

The phases are deliberate. Each one prepares the system for the next. Doing them out of order, or all at once, is where most protocols fail.

Phase 1
Remove Blocks and Restore Methylation
Weeks 1-12

Remove synthetic folic acid (fortified foods, standard prenatals)

Methylfolate (5-MTHF) and active B12

Methylcobalamin (B12) spray

Hydroxocobalamin B12 injections: 1,000 μg 2x/week (first 8 weeks)

Phase 2
Restore Nutrient Foundations
Weeks 1-16

Iron bisglycinate

Zinc, molybdenum, selenium, and silica

Phase 3
Restore Gut Function
Weeks 1-20

Anti-inflammatory diet: removed gluten, dairy, processed foods for 8 weeks

Digestive enzymes with meals

Spore-based probiotic

Prebiotic fibre (PHGG)

Phase 4
Rebuild Glutathione and Detox
Weeks 1-20

Alpha-lipoic acid

Vitamin C

Molybdenum (covered in AFM Formula A above)

Phase 5
Optimise Thyroid and Hormones for Conception
Weeks 1-12

Selenium (covered in AFM Formula A above)

Omega-3 (EPA/DHA)

Monitor TSH every 6-8 weeks (target <2.0 for conception)

Phase 6
Reduce Physiological Load
Ongoing

Sleep hygiene: 7-8 hours nightly

Stress modulation: daily breathwork, yoga

Phase 7
Prepare for Conception
Weeks 8+
Duration 8 months

Markers  back to baseline.

The biomarkers tell the story. Every value moved from "abnormal" to "optimal" within six months of the protocol going live.

Homocysteine
12.6 6.2 Optimal ✓
Active B12
42 580 pmol/L Optimal ✓
Ferritin
28 92 (optimal) Optimal ✓
Vitamin D
52 135 nmol/L Optimal ✓
TSH
2.4 1.4 Optimal ✓
Progesterone (Day 21)
26 42 Optimal ✓
CRP
2.8 0.6 Resolved ✓
Pyroglutamic acid
38.5 19.8 Restored ✓
Calprotectin
88 22 Normal ✓

Conceived naturally at Month 9. Two subsequent pregnancies carried to term.

Read the full clinical story

Claire's case is  Chapter  15.

The reasoning behind every decision, the sequencing logic, the diagnostic interpretation, and the framework these protocols sit inside, all of it is in the book.

Important. This protocol was designed for a specific individual based on their unique test results, medical history, genetics, and clinical context. It is presented here for educational purposes only and should not be replicated without professional guidance.

Every person requires an individualised approach. Work with a qualified practitioner who can assess your situation, interpret your test results, and design a protocol tailored to your needs. Supplement links are provided for reference to the practitioner-grade products used in this case. This information does not constitute medical advice, diagnosis, or treatment.