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Case Study

Alex

Anxiety & Neurotransmitters
Chapter Chapter 13
Duration 5 months
Status Resolved
Before Severe panic attacks and anxiety.
After Five months to complete symptom resolution.
The Story

Neurotransmitters and Undermethylation

Alex was 21, a university student whose life had been taken over by panic attacks, severe anxiety, racing thoughts, and insomnia. His GP put him on an SSRI and told him it was college stress. But Alex had never been anxious before university.

Something had changed, and nobody was looking for what. His organic acids test revealed severely depleted dopamine and serotonin precursors, critically low glutathione, and high Clostridia markers producing neurotoxins in his gut. His blood work showed a pyrrole disorder that was chronically depleting his zinc and B6, the very nutrients his brain needed to manufacture its own neurotransmitters. The SSRI was treating the symptom. The underlying drivers had never been identified.

The full clinical story Chapter 13 of The Healing Hierarchy Get the Book →
Diagnostics

What we tested. And what we found.

Every protocol in The Healing Hierarchy starts with comprehensive testing. The right tests reveal the actual drivers. Without them, you're treating symptoms.

Tests Used Key Findings
Pyrrole Disorder
Elevated kryptopyrroles
Chronic B6 and Zinc depletion
Xanthurenate
85
Normal : < 40
Severe B6 deficiency
Zinc
8.9 μmol/L
Optimal : 12-18
Severely low
Copper
29 μmol/L
Optimal : 11-24
Poor Cu:Zn ratio
Homocysteine
12.4
Optimal : < 7
Undermethylation confirmed
Pyroglutamic acid
41.5
Normal : ≤ 28
Severe glutathione depletion
HVA
Very low
5-HIAA
Low
High Clostridia markers
Neurotoxin-producing bacteria
CRP
28
Optimal : < 1.0
Vitamin D
32 nmol/L
Optimal : 80-200
The Protocol

Sequenced,  not stacked.

The phases are deliberate. Each one prepares the system for the next. Doing them out of order, or all at once, is where most protocols fail.

Phase 1
Stabilise Nervous System and Clear Gut Interference
Weeks 1-8

Herbal antimicrobials (Clostridia-targeted)

Magnesium glycinate nightly

Breathwork: 5 min morning and night

Phase 2
Restore Core Nutrient Deficiencies
Weeks 1-12

Zinc, selenium, molybdenum, and silica

Vitamin B6 (P-5-P) and magnesium

Iron bisglycinate

Methylated B-complex

Phase 3
Restore Methylation and Neurotransmitter Synthesis
Weeks 1-16

Continue zinc, B6, methylated B vitamins

Phase 4
Rebuild Glutathione and Detox Capacity
Weeks 1-20
Phase 5
Support Neurotransmitter Balance
Weeks 8+

5-HTP (serotonin precursor, for sleep/mood)

L-Tyrosine (dopamine precursor, for focus)

Introduced only after gut and methylation stabilised

Phase 6
Dietary and Lifestyle
Ongoing

Protein-rich breakfast, no skipping meals

Blood sugar stabilisation Reduce energy drinks and refined carbs

Sleep hygiene Magnesium + L-theanine 30 min before bed, 7-8 hours, screen time reduction

Sun exposure 15-20 min daily

Walk between classes, reduce caffeine after 2 PM

Duration 5 months

Markers  back to baseline.

The biomarkers tell the story. Every value moved from "abnormal" to "optimal" within six months of the protocol going live.

Xanthurenate
85 28 Normal ✓
Zinc
8.9 13.8 Optimal ✓
Copper
29 19 Balanced Cu:Zn ratio ✓
Homocysteine
12.4 6.8 Optimal ✓
Pyroglutamic acid
41.5 21.2 Glutathione restored ✓

Panic attacks stopped within 6 weeks. Sleeping through the night. Grades improved from C's to A's/B's. Came off SSRI under medical supervision.

Read the full clinical story

Alex's case is  Chapter  13.

The reasoning behind every decision, the sequencing logic, the diagnostic interpretation, and the framework these protocols sit inside, all of it is in the book.

Important. This protocol was designed for a specific individual based on their unique test results, medical history, genetics, and clinical context. It is presented here for educational purposes only and should not be replicated without professional guidance.

Every person requires an individualised approach. Work with a qualified practitioner who can assess your situation, interpret your test results, and design a protocol tailored to your needs. Supplement links are provided for reference to the practitioner-grade products used in this case. This information does not constitute medical advice, diagnosis, or treatment.